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Title   유암조직에서 카뎁신 - D 의 발현과 임상별리학적 예후인자들과의 상관관계 ( Immunohistochemical Assay of Cathepsin - D in Breast Carcinomas : Comparison with Age Tumor Siae , Lymphnode Invasiveness and Estrogen Receptor )
Publicationinfo   1993 Jan; 025(05): 658-664.
Key_word   Breast cancer, Cathepsin-D
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Abstract   Cathepsin-D is considered to be an independent prognostic factor in breast cancer vatients from many other studies. We hsve performed immunohistochemical assay with polyclonal antibody specific to the cathepsin-D in paraffin blocks of one hundred and one breast cancer specimens. All the patients were female and positive ratio of cathepsin-D was 58.4%(59 cases). These results were compared with ER status, tumor size, lymphnode invasion and with the age of the patients. In the patients with age less than fifty years old, thirty four cases(52.3%) were cathepsin-D positive, and twenty five cases(69.4%) were cathepsin-D positive in older than fifty years of age. In the relationship with size of tumors, ten cases(50.0%) were positive in the tu- mors smaller than 2cm, thirty six cases(62.1%) were positive in the tumors with the size between 2 cm and 5 cm and thirteen cases(56.5%) were positive with the tumors larger than 5 cm. With respect to the axillary lymphnode involvement, twenty five cases(55.6%) were paaitive in the negative group and twelve eases(57.1%) were positive with the group less than four lymphnodes involvement and twenty two cases(62.9%) were positive in the group four or more lymphnodes involvement. In the ER negative group nineteen cases(55.9%) were positive and thirty one cases(58.5%) were positive in ER positive graup. In the results of our study, there were little relationships between cathepsin-D and other classical prognostic factors including estrogen receptor in breast carcinoma patients.
저 자   한세환(Se Hwan Han),노동영(Dong Young Noh),최국진(Kuk Jin Choe),김진복(Jin Pok Kim),이왕재(Wang Jae Lee),박인애(In Ae Park)